Role of Reactive Oxygen Species in the Regulation of Physiological Functions.

• NOSE Kiyoshi

抄録

Bio-organisms possess numerous systems that produce reactive oxygen species (ROS). Severe oxidative stress induces cellular damage that can lead to apoptosis or necrosis, but moderate ROS levels constitute and modulate normal and critical physiological pathways in the regulation of cellular functions, including signaling cascades and transcriptional/post-transcriptional control of gene expression. ROS are also found to mimic some of the physiological stimuli by direct modification of factors or indirect mechanisms via change in the oxidative and reductive status inside/outside cells. This review will describe the biological relevance and essential roles of ROS in animal cells, focusing on signal transduction, gene expression, apoptosis and aging.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 23 (8), 897-903, 2000

  公益社団法人 日本薬学会

キーワード

• active oxygens
• signal transduction
• gene expression

詳細情報

• CRID: 1390282679603681408
• NII論文ID: 110003640090
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.23.897
• COI: 1:CAS:528:DC%2BD3cXlsFamsro%3D
• ISSN: 13475215
• ISSN: 09186158
• ISSN: http://id.crossref.org/issn/09186158
• NDL書誌ID: 5431134
• PubMed: 10963291
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I5431134
• Web Site: http://www.jstage.jst.go.jp/article/bpb1993/23/8/23_8_897/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2001004252
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可