Mitochondria-Selective Reduction of 62Cu-Pyruvaldehyde Bis(N4-methylthiosemicarbazone)(62Cu-PTSM) in the Murine Brain; a Novel Radiopharmaceutical for Brain Positron Emission Tomography(PET) Imaging.

• 藤林 靖久

• 和田 耕一

• 谷内 秀之

• 米倉 義晴

• 小西 淳二

• 横山 陽

抄録

The retention mechanism of ⁶²Cu-pyruvaldehyde bis(N⁴-methylthiosemicarbazone) (⁶²Cu-PTSM) in the murine brain was evaluated. For this purpose, stable Cu-PTSM was subjected to electron spin resonance spectrometry (ESR) and high performance liquid chromatography (HPLC) analysis to determine the valence state, coordination structure and tissue metabolism. In murine brain homogenate, ESR and HPLC analysis indicated the reduction and cleavage of Cu(II)-PTSM to Cu(I). This virtually irreversible reduction was specifically initiated by the mitochondrial enzymatic system in the murine brain.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 16 (2), 146-149, 1993

  公益社団法人 日本薬学会

キーワード

• ^<62>Cu-PTSM
• brain
• retention mechanism
• perfusion imaging
• mitochondria
• reduction

詳細情報

• CRID: 1390282679598112000
• NII論文ID: 110003640200
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.16.146
• ISSN: 13475215
• ISSN: 09186158
• PubMed: 8395929
• Web Site: http://www.jstage.jst.go.jp/article/bpb1993/16/2/16_2_146/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1995085833
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可