Inhibitory Effect of Karounidiol on 12-O-Tetradecanoylphorbol-13-acetate-Induced Tumor Promotion.

• 安川 憲

• 秋久 俊博

• 田村 利武

• 滝戸 道夫

抄録

Karounidiol [D : C-Friedo-oleana-7, 9 (11)-diene-3α, 29-diol] and 7-oxodihydrokarounidiol [7-oxo-D : C-friedo-olean-8-ene-3α, 29-diol], isolated from the seeds of Trichosanthes kirilowii, were examined for the effect on 12-O-tetradecanoylphorbol-13-acetate (TPA, 1μg/ear)-induced inflammation, following application of this tumorpromoting agent, to the ears of mice. Both compounds inhibited the inflammatory activity induced by TPA and the 50% inhibitory dose for TPA-induced inflammation was 0.3 and 0.4 mg/ear, respectively. Furthermore, at 2 μmol/mouse, karounidiol markedly suppressed the promoting effect of TPA (1 μg/mouse) on skin tumor formation in mice following initiation with 7, 12-dimethylbenz [a] anthracene (50 μg/mouse).

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 17 (3), 460-462, 1994

  公益社団法人 日本薬学会

キーワード

• karounidiol
• antitumor promotion
• two-stage carcinogenesis
• D : C-friedo-oleanane triterpene
• antiinflammation
• 12-O-tetradecanoylphorbol-13-acetate

詳細情報

• CRID: 1390282679598348288
• NII論文ID: 110003640566
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.17.460
• ISSN: 13475215
• ISSN: 09186158
• PubMed: 8019519
• Web Site: http://www.jstage.jst.go.jp/article/bpb1993/17/3/17_3_460/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1995082625
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可