Kinetic Analysis of Neuromuscular Blockade. II. Train-of-Four Fade Induced by d-Tubocurarine and .ALPHA.-Bungarotoxin.

• 田島 武志

• 加藤 安宏

• 畑中 朋美

• 合葉 哲也

• 片山 和憲

• 小泉 保

抄録

The degree of train-of-four (TOF) fade, i.e., the reduction of the fourth to the first twitch height in a train, induced by d-tubocurarine (d-TC) and α-bungarotoxin (α-BX) was investigated. The fade induced by d-TC was pronounced in comparison with that by α-BX, and the difference was analyzed using a kinetic model. Based on the assumptions : (1) Acetylcholine (ACh) binds to the nicotinic receptor and evokes twitch response. (2) The amount of released ACh is dependent on stimulus interval. (3) d-TC interacts competitively with the receptor. (4) α-BX interacts irreversibly with the receptor. It was suggested that the fade by d-TC and α-BX can be explained by the difference of the receptor occupancy by ACh which was caused by different interaction mechanisms of the two muscle relaxants with receptors.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 17 (8), 1089-1093, 1994

  公益社団法人 日本薬学会

キーワード

• train-of-four fade
• d-tubocurarine
• α-bungarotoxin
• acetylcholine
• pharmacodynamics
• pharmacokinetics

詳細情報

• CRID: 1390001204623373696
• NII論文ID: 110003640712
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.17.1089
• ISSN: 13475215
• ISSN: 09186158
• PubMed: 7820114
• Web Site: http://www.jstage.jst.go.jp/article/bpb1993/17/8/17_8_1089/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1995191747
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可