Caffeine Enhances Adriamycin Antitumor Activity in Ehrlich Ascites Carcinoma-Bearing Mice.

• 佐塚 泰之

• 望月 英子

• 岩崎 綾乃

• 広田 貞雄

• 滝野 吉雄

抄録

We examined whether caffeine enhances the antitumor activity of adriamycin (ADR), in terms of prolonging survival in Ehrlich ascites carcinoma (ascites-type)-bearing mice. After administration of ADR at a dose of 0.5 mg/kg/d for 5 d together with caffeine (100 mg/kg/d×5 d), the survival period was increased by 39%. However, caffeine had little effect on this ADR induced-prolongation of survival following administration of ADR at 2.0 mg/kg/d for 4 d. Although a significant increase in ADR concentration in the ascites tumor was seen after administration of ADR at a dose of 0.5 mg/kg, caffeine failed to increase ADR concentration in the ascites tumor after administration of ADR at a dose of 2.0 mg/kg. The effect of caffeine thus appears to be due to its effect on the tumor distribution of ADR.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 18 (1), 159-161, 1995

  公益社団法人 日本薬学会

キーワード

• biochemical modulation
• caffeine
• adriamycin
• Ehrlich ascites carcinoma
• adriamycin concentration

詳細情報

• CRID: 1390282679599430784
• NII論文ID: 110003640759
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.18.159
• COI: 1:CAS:528:DyaK2MXksVWksLk%3D
• ISSN: 13475215
• ISSN: 09186158
• PubMed: 7735232
• Web Site: http://www.jstage.jst.go.jp/article/bpb1993/18/1/18_1_159/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1995243829
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可