Noninvasive Measurement of Cerebral Blood Flow and Glucose Metabolic Rate in the Rat with High-Resolution Animal Positron Emission Tomography(PET): A Novel in Vivo Approach for Assessing Drug Action in the Brains of Small Animals.

• 間賀田 泰寛

• 佐治 英郎

• 崔 錫禮

• 田島 健

• 高垣 武司

• 笹山 哲

• 米倉 義晴

• 北野 治廣

• 渡辺 光男

• 岡田 裕之

• 吉川 悦次

• 山下 貴司

• 横山 陽

• 小西 淳二

抄録

The cerebral metabolic rate of glucose (CMRglc) and cerebral blood flow (CBF) in rats were estimated noninvasively with a high-resolution animal positron emission tomography (PET) system that we recently developed. Quantifications of CMRglc and CBF were attempted with radiotracers, ¹⁸F-2-fluoro-2-deoxyglucose and ¹⁵O-water, respectively. From the data obtained with PET, the CMRglc and CBF values under pretreatment conditions were respectively calculated as 51±14μmol/min/100g and 61±7ml/min/100g under pentobarbital-anesthesia. These values were in close agreement with published data obtained with the autoradiographic technique. Moreover, and increase of 69% (mean) in CBF was detected after i.v. acetazolamide administration. The results indicate that this high-resolution animal PET scanner holds great potential for the assessment of drug-related metabolic and circulatory effects in intact and experimental animals.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 18 (5), 753-756, 1995

  公益社団法人 日本薬学会

キーワード

• animal positron emission computed tomography
• ^<18>F-2-fluoro-2-deoxy-glucose
• ^<15>O-water
• glucose cerebral metabolic rate
• cerebral blood flow
• rat brain

詳細情報

• CRID: 1390282679600465664
• NII論文ID: 110003640922
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.18.753
• COI: 1:CAS:528:DyaK2MXnsVajtL8%3D
• ISSN: 13475215
• ISSN: 09186158
• ISSN: http://id.crossref.org/issn/09186158
• PubMed: 7492995
• Web Site: http://www.jstage.jst.go.jp/article/bpb1993/18/5/18_5_753/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1996021624
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可