Lack of Potentiation with Felbinac Patch on the Convulsive Toxicity of Enoxacin in Rats.

• OHTANI Hisakazu

• NOMA Sonoe

• KAWAKAMI Junichi

• SAWADA Yasufumi

• IGA Tatsuji

抄録

We investigated the possible potentiation of the convulsive toxicity of enoxacin (ENX) by the concomitant topical application of a felbinac (FLB) patch in rats. A felbinac patch (Seltouch^[○!R]; 0.5%, 3 cm×4 cm) was attached on the back of rats where their hair has been removed. ENX was infused from the left jugular vein at 8 h after the application of FLB patch under an unanesthetized and unstrained condition. Blood, CSF and brain samples were collected at the occurrence of convulsion, and ENX concentrations of each part were determined.As a result, no significant potentiation by FLB patch was found in the onset time of convulsion or in the ENX concentration of each part. Moreover, based on the assumption that there are no inter-species differences in ENX concentration in the brain at the occurrence of a convulsion (C_br), the predicted plasma ENX concentration required to elicit convulsions in humans, which was estimated from the C_br and K_p value of ENX in the brain of rats, was 20 times higher than the therapeutic plasma level.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 19 (7), 995-997, 1996

  公益社団法人 日本薬学会

キーワード

• convulsion
• enoxacin
• felbinac
• patch
• NSAID
• new quinolone

詳細情報

• CRID: 1390282679600029184
• NII論文ID: 110003641307
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.19.995
• ISSN: 13475215
• ISSN: 09186158
• PubMed: 8839976
• Web Site: http://www.jstage.jst.go.jp/article/bpb1993/19/7/19_7_995/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1997000623
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可