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- Kondoh Masuo
- Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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- Ogasawara Satoko
- Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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- Araragi Saeko
- Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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- Higashimoto Minoru
- Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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- Sato Masao
- Faculty of Pharmaceutical Sciences, Tokushima Bunri University
この論文をさがす
抄録
Cadmium (Cd) induces apoptosis in vitro and in vivo. However, the mode of action is unclear. Cytochrome C (Cyt c) release from mitochondria into cytoplasm is a key event in apoptosis. In this study, we examined the effects of Cd on the release of Cyt c from mitochondria using human leukemia HL-60 cells and isolated mitochondria. Cd induced apoptosis in HL-60 cells in a dose-dependent manner, in accordance with increases in cytosolic Cyt c. Cd at 25 μM also induced the release of Cyt c from isolated mitochondria. Mitochondrial swelling induced by permeability transition is known to cause outer membrane rupture and Cyt c release from mitochondria. Cd induced a swelling of mitochondria in vitro, as did calcium, a classical inducer of mitochondrial permeability transition. These results suggest that apoptosis induced by Cd appears to be involved in a mitochondria-dependent pathway and in the release of Cyt c from mitochondria by swelling.
収録刊行物
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- JOURNAL OF HEALTH SCIENCE
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JOURNAL OF HEALTH SCIENCE 47 (1), 78-82, 2001
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204497649280
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- NII論文ID
- 110003641378
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- NII書誌ID
- AA11316464
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- COI
- 1:CAS:528:DC%2BD3MXhtFygtbs%3D
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- ISSN
- 13475207
- 13449702
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- NDL書誌ID
- 5655029
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可