Inhibitory Effect of Plant Extracts on Production of Verotoxin by Enterohemorrhagic Escherichia coli O157 : H7.

• Sakagami Yoshikazu

  Osaka Prefectural Institute of Public Health

• Murata Hiroko

  Faculty of Pharmaceutical Sciences, Setsunan University

• Nakanishi Tsutomu

  Faculty of Pharmaceutical Sciences, Setsunan University

• Inatomi Yuka

  Faculty of Pharmaceutical Sciences, Setsunan University

• Watabe Kazuhito

  Faculty of Pharmaceutical Sciences, Setsunan University

• Iinuma Munekazu

  Gifu Prefectural Institute of Health and Environmental Sciences

• Tanaka Toshiyuki

  Gifu Prefectural Institute of Health and Environmental Sciences

• Murata Jin

  Botanical Gardens, Graduate School of Science, the University of Tokyo

• Lang Frank A.

  Department of Biology, Southern Oregon University

Abstract

The inhibitory effect of several plant extracts on the production of verotoxin by enterohemorrhagic Escherichia coli O157 : H7 (EHEC) was investigated. The extracts from four plant species, Limonium californicum (Boiss.) A. Heller, Cupressus lustianica Miller, Salvia urica Epling and Jusiaea peruviana L., were effective on the inhibition for verotoxin production (31.3-125 μg/ml). The inhibition against verotoxin production was observed at a concentration lower than the minimal inhibitory concentration (MIC) of each extract of test plants (1000 μg/ml), indicating that these plant extracts would preferentially prevent the production of verotoxin rather than bactericidal effect on EHEC. These findings suggest that the administration of any appropriate plant extract might prevent the production of verotoxin on EHEC in the human intestines.

Journal

• Journal of Health Science

  Journal of Health Science 47 (5), 473-477, 2001

  The Pharmaceutical Society of Japan

Keywords

• plants extract
• enterohemorrhagic E. coli O157 : H7
• inhibitory effect of verotoxin production

Details

• CRID: 1390282679473692672
• NII Article ID: 110003641434
• NII Book ID: AA11316464
• DOI: 10.1248/jhs.47.473
• COI: 1:CAS:528:DC%2BD3MXnvFans78%3D
• ISSN: 13475207
• ISSN: 13449702
• NDL BIB ID: 5923311
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I5923311
• Web Site: http://www.jstage.jst.go.jp/article/jhs/47/5/47_5_473/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2002071388
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed