Passage of Bisphenol A into the Fetus of the Pregnant Rat

• Miyakoda Hidekazu

• Tabata Masako

• Onodera Sukeo

• Tkeda Ken

抄録

We examined whether orally administered bisphenol A transfers from the maternal rat to the fetus. After oral dose of 10mg/kg bisphenol A, it immediately appeared in maternal blood, and transferred into the fetuses. The concentration of bisphenol A in both maternal blood plasma and fetuses peaked within 1h after administration. The values were approximately 34 ppb and 11ppb, respectively. At 3h, the concentration of bisphenol A in maternal blood plasma had decreased to approximately 10% of the peak value. The 3-h decrease in fetuses was only about 40% of the peak, and by 24h, the fetal concentration had increased again to the nearly 70% of the peak value. The results suggest that bisphenol A might easily pass through the placental barrier, unlike sex hormones such as estrogen.

収録刊行物

• ＪＯＵＲＮＡＬ　ＯＦ　ＨＥＡＬＴＨ　ＳＣＩＥＮＣＥ

  ＪＯＵＲＮＡＬ　ＯＦ　ＨＥＡＬＴＨ　ＳＣＩＥＮＣＥ 45 (6), 318-323, 1999

  公益社団法人 日本薬学会

キーワード

• plasma

詳細情報

• CRID: 1390282679474576768
• NII論文ID: 110003641578
• NII書誌ID: AN00021540
• ISSN: 0013273X
• ISSN: 13475207
• ISSN: 13449702
• ISSN: http://id.crossref.org/issn/13449702
• DOI: 10.1248/jhs.45.318
• COI: 1:CAS:528:DC%2BD3cXjs1Cnug%3D%3D
• NDL書誌ID: 4951608
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4951608
• Web Site: http://www.jstage.jst.go.jp/article/jhs1999/45/6/45_6_318/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2000163279
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可