フェニトインの剤形変更に伴う血清中濃度の上昇 : 症例と要因の解析 An Increase in Serum Phenytoin Concentration by Changes of Dosage Form : Case Reports and Its Mechanism

この論文にアクセスする

著者

抄録

Phenytoin (PHT) exhibits nonlinear pharmacokinetics in the therapeutic range. Therefore a slight increase in dose may lead to considerable elevation of the serum PHT level. Although its bioavailability is dependent on the formulation, bioequivalence is considered to be preserved between the three major formulations, of tablet, 97% fine granules, and 10% powder. However, we experienced many cases of increases serum PHT concentration after changes in formulation from 97% fine granules to 97/4% hospital-made fine granules, and from the latter to 10% powder. Retrospective analysis revealed that these alterations were accompanied by 55% and 16% increases in the serum concentration-to-dose ratio of PHT, respectively. We investigated the factors of this increase by analyzing the weight of remaining powder in a package and the PHT content of each formulation. Each package of PHT formulation prepared with 97% fine granules and 10% powder was unsealed, and the contents were weighed to calculate the rate of recovery. The rate of ingestion was estimated by correcting the rate of recovery by PHT strength (i. e., 1.0 for 10% powder and 0.97 for fine granules). The rates of recovery and ingestion for 10% powder were 13% and 16% higher than those for 97% fine granules, respectively (<i>p</i><0.01). In conclusion, Changing the PHT formulation from 97% fine granules to 10% powder may lead to a considerable increase in the serum PHT concentration and possibly induce PHT toxicity.<br>

収録刊行物

  • 藥學雜誌 = Journal of the Pharmaceutical Society of Japan

    藥學雜誌 = Journal of the Pharmaceutical Society of Japan 122(5), 331-338, 2002-05-01

    公益社団法人日本薬学会

参考文献:  10件中 1-10件 を表示

  • <no title>

    PLAA G. L.

    Arch. Int. Pharmacodyn. Ther. 128, 375, 1960

    被引用文献1件

  • <no title>

    BESELT R. C.

    Clin. Chem. 21, 44-62, 1975

    被引用文献1件

  • <no title>

    MASUR H.

    Neurology 39, 432-433, 1989

    被引用文献1件

  • <no title>

    BOREUS L. O.

    J. Neurol. 223, 241-249, 1980

    被引用文献1件

  • <no title>

    DAINIPPON PHARMACEUTICAL CO. Ltd

    Bioavailabilities of ALEVIATIN Fine Granules and ALEVIATIN 10% Powder

    被引用文献1件

  • <no title>

    SHIMIZU Y.

    J. Jpn. Soc. Hosp. Pharm. 30, 459-462, 1994

    被引用文献1件

  • <no title>

    EMORI K.

    Abstracts of papers, the 32nd Annual Meeting of Japan Epilepsy Society, Yokohama, 1998 127

    被引用文献1件

  • Cerebellar Atrophy After Acute Phenytoin Intoxication

    KURUVILLA Thomas , BHARUCHA N. E.

    Epilepsia : journal of the International League against Epilepsy 38(4), 500-502, 1997-04-01

    参考文献10件 被引用文献3件

  • <no title>

    重松誠

    J. Jpn. Soc. Hosp. Pharm. 26, 865-869, 1990

    医中誌Web  被引用文献3件

  • <no title>

    MAMIYA K.

    Epilepsia 39, 1317-1323, 1998

    DOI  被引用文献3件

被引用文献:  4件中 1-4件 を表示

各種コード

  • NII論文ID(NAID)
    110003648448
  • NII書誌ID(NCID)
    AN00284903
  • 本文言語コード
    JPN
  • 資料種別
    ART
  • ISSN
    00316903
  • NDL 記事登録ID
    6151265
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z19-411
  • データ提供元
    CJP書誌  CJP引用  NDL  NII-ELS  J-STAGE 
ページトップへ