Microbial Growth-Promotion Activity of 3-Hydroxymonoazine- and N-Hydroxydiazine-Type Heterocycles

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  • SAITO Ryota
    Department of Applied Chemistry, Faculty of Engineering, Seikei University
  • GHOSH Kallol K.
    Department of Applied Chemistry, Faculty of Engineering, Seikei University
  • HARADA Kazuo
    Department of Life Science, Tokyo Gakugei University
  • KATOH Akira
    Department of Applied Chemistry, Faculty of Engineering, Seikei University

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タイトル別名
  • Microbial Growth-Promotion Activity of 3-Hydroxymonoazine- and <i>N</i>-Hydroxydiazine-Type Heterocycles

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Three 3-hydroxymonoazine- and three N-hydroxydiazine-type heterocycles were tested whether they act as artificial siderophores toward Aureobacterium flavescens JG-9 (ATCC No. 25091). Among them, 1-hydroxy-3,5,6-trimethyl-2(1H)-pyrazinone (3) showed the highest growth-promotion activity comparable to desferrioxamine B (DFB), a natural trihydroxamate siderophore, at 48.5μM or above, followed by 1-hydroxy-5,6-dimethyl-2(1H)-pyrazinone (2), 1-hydroxy-4,6-dimethyl-2(1H)-pyrimidinone (1), and 3-hydroxy-2-methyl-1-phenyl-4(1H)-pyridinone (6), while 3-hydroxy-1,2-dimethyl-4(1H)-pyridinone (5) did not show the bioactivity. These results are the first examples of N-hydroxydiazine-type heterocycles acting as artificial siderophores for A. flavescens JG-9.<br>

収録刊行物

  • 薬学雑誌

    薬学雑誌 122 (9), 703-705, 2002-09-01

    公益社団法人 日本薬学会

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