活性酸素による生体障害に関する研究(第1報) : アロキサン糖尿病発症に対する種々ハイドロキシル・ラジカル消去剤の防御作用(生物学及び生化学)

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タイトル別名
  • Studies on Biological Damage by Active Oxygen. I. : Protective Effect of Various Hydroxyl Radical Scavengers against Alloxan-Induced Diabetes (Biological)
  • 活性酸素による生体障害に関する研究-1-アロキサン糖尿病発症に対する種々ハイドロキシル・ラジカル消去剤の防御作用
  • カッセイ サンソ ニ ヨル セイタイ ショウガイ ニ カンスル ケンキュウ 1

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抄録

Protective effects of several hydroxyl radical (HO·) scavengers and superoxide dismutase on alloxan-induced diabetes were studied in vivo. Thiourea, methylthiourea, dimethylthiourea and ethanol, HO· scavengers (type 1), which easily cross cellular membranes, protected initial- and permanent-hyperglycemia. In contrast, mannitol and sorbitol (type 2), which can not cross cellular membranes, protected initial-hyperglycemia, but did not protect permanent-hyperglycemia. Furthermore, superoxide dismutase which is not expected to be incorporated into pancreatic β-cell, strongly protected initial-hyperglycemia but partially protected permanent-hyperglycemia. These results suggest that HO·primarily damages the β-cell membranes by acting at or neat a site involved in insulin release, and subsequently damages the intracellular components. From these results, the possible protective mechanism of these scavengers was discussed.

収録刊行物

  • 薬学雑誌

    薬学雑誌 106 (11), 1034-1039, 1986

    公益社団法人 日本薬学会

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