パラオキシ安息香酸エステル類のヒトエストロゲン受容体αとβ結合作用

• 佐藤 かな子

• 長井 二三子

• 青木 直人

• 西島 基弘

書誌事項

タイトル別名

• Competitive Binding of Some Alkyl p-Hydroxybenzoates to Human Estrogen Receptor α and β
• パラオキシ アンソクコウサン エステルルイ ノ ヒトエストロゲン ジュヨウタイ アルファ ト ベータ ケツゴウ サヨウ
• Competitive Binding of Some Alkyl p-Hydroxybenzoates to Human Estrogen Receptor α and β

抄録

Alkyl p-hydroxybenzoates such as isobutyl p-hydroxybenzoate (PHBA-iBu), butyl p-hydroxybenzoate (PHBA-nBu), isopropyl p-hydroxybenzoate (PHBA-iPr), propyl p-hydroxybenzoate (PHBA-nPr), ethyl p-hydroxybenzoate (PHBA-Et), and methyl p-hydroxybenzoate (PHBA-Me) are widely used as preservatives, stabilizers and antiseptics for medical supplies, cosmetics, foodstuffs etc. We determined the binding affinity of alkyl p-hydroxybenzoates to human estrogen receptor α (ERα) and β (ERβ) by non-RI receptor binding assays. PHBA-iBu had a high binding affinity for ERα (IC₅₀ : 6.0×10^-6M, the relative binding affinity (RBA) : 0.267) and ERβ (IC₅₀ : 5.0×10^-6M, RBA : 0.340). These IC₅₀ values and RBA were almost the same as those of bisphenol A. The ranking of the estrogenic potency of alkyl p-hydroxybenzoates for both ERs is different; that is, PHBA-iBu>PHBA-nBu≒PHBA-iPr≒PHBA-nPr>PHBA-Et»PHBA-Me. Alkyl p-hydroxybenzoates bound with equal relative affinity to both ERα and β proteins. Alkyl p-hydroxybenzoate having a long alkyl side-chain showed a high affinity for ERα and β. These findings suggest that p-hydroxybenzoates may be endocrine disruptors.

収録刊行物

• 薬学雑誌

  薬学雑誌 120 (12), 1429-1433, 2000

  公益社団法人 日本薬学会

キーワード

• p-hydroxybenzoate
• human estrogen receptor α
• human estrogen receptor β
• endocrine disruptor
• diethylstilbestrol
• bisphenol A

詳細情報

• CRID: 1390001206153653760
• NII論文ID: 130007275603
• NII論文ID: 110003648796
• NII書誌ID: AN00284903
• DOI: 10.1248/yakushi1947.120.12_1429
• ISSN: 13475231
• ISSN: 00316903
• ISSN: http://id.crossref.org/issn/00316903
• NDL書誌ID: 5601148
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I5601148
• Web Site: https://www.jstage.jst.go.jp/article/yakushi1947/120/12/120_12_1429/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2001095511
• データソース種別:
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  • NDL
  • Crossref
  • CiNii Articles
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