フグ毒研究の最近の進歩 Recent Advances in Tetrodotoxin Research

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著者

    • 松居 隆 MATSUI Takashi
    • 東京大学大学院農学生命科学研究科水産化学研究室 The Laboratory of Marine Biochemistry, Graduate School of Agricultural Life Science, The University of Tokyo
    • 大塚 幸 OHTSUKA Yukio
    • 九州大学大学院医学研究院法医学分野 Department of Forensic Pathology and Sciences, Graduate School of Medical Science, Kyushu University

抄録

One century has passed since fugu toxin was named tetrodotoxin (TTX) by Tahara. Chemical problems such as crystallization of tetrodotoxin and subsequent structure determination were solved by research groups headed by Tsuda, Hirata, Woodward, and Mosher. The International Symposium on the Chemistry of Natural Products in Kyoto (1964) was well known as symposium which the structure of TTX was internationally clarified. Since the first isolation of toxin from taricha torosa (imori) as natural source except for fugu fishes, distribution of toxin in nature has been widely investigated. And, it was proved that toxin is not produced by fugu fishes, but rather is formed by sea bacteria (30 sp.) such as Alteromonas sp, Vibrio sp, Shewanella. However, it seems to be difficult to explain the tetrodotoxin accumulation at high concentration in fugu by only toxin production by bacteria. TTX analogues were isolated from natural origins such as crabs, fish, annelids, and algae. Based on the structure of these toxin analogues, the biosynthesis of toxin and the structure-activity relationship (Na^+ channel) were proposed by Yasumoto-Yamashita. The findings of wide distribution of toxin in nature may be attributed to development of highly sensitive detection method for toxin. The interesting proposal for the biosynthesis and the structure activity, and the detection method for toxin are outlined in this review.

収録刊行物

  • 藥學雜誌 = Journal of the Pharmaceutical Society of Japan

    藥學雜誌 = Journal of the Pharmaceutical Society of Japan 120(10), 825-837, 2000-10-01

    公益社団法人日本薬学会

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各種コード

  • NII論文ID(NAID)
    110003648867
  • NII書誌ID(NCID)
    AN00284903
  • 本文言語コード
    JPN
  • 資料種別
    REV
  • ISSN
    00316903
  • NDL 記事登録ID
    5504592
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z19-411
  • データ提供元
    CJP書誌  CJP引用  NDL  NII-ELS 
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