フグ毒研究の最近の進歩  [in Japanese] Recent Advances in Tetrodotoxin Research  [in Japanese]

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Author(s)

    • 松居 隆 MATSUI Takashi
    • 東京大学大学院農学生命科学研究科水産化学研究室 The Laboratory of Marine Biochemistry, Graduate School of Agricultural Life Science, The University of Tokyo
    • 大塚 幸 OHTSUKA Yukio
    • 九州大学大学院医学研究院法医学分野 Department of Forensic Pathology and Sciences, Graduate School of Medical Science, Kyushu University

Abstract

One century has passed since fugu toxin was named tetrodotoxin (TTX) by Tahara. Chemical problems such as crystallization of tetrodotoxin and subsequent structure determination were solved by research groups headed by Tsuda, Hirata, Woodward, and Mosher. The International Symposium on the Chemistry of Natural Products in Kyoto (1964) was well known as symposium which the structure of TTX was internationally clarified. Since the first isolation of toxin from taricha torosa (imori) as natural source except for fugu fishes, distribution of toxin in nature has been widely investigated. And, it was proved that toxin is not produced by fugu fishes, but rather is formed by sea bacteria (30 sp.) such as Alteromonas sp, Vibrio sp, Shewanella. However, it seems to be difficult to explain the tetrodotoxin accumulation at high concentration in fugu by only toxin production by bacteria. TTX analogues were isolated from natural origins such as crabs, fish, annelids, and algae. Based on the structure of these toxin analogues, the biosynthesis of toxin and the structure-activity relationship (Na^+ channel) were proposed by Yasumoto-Yamashita. The findings of wide distribution of toxin in nature may be attributed to development of highly sensitive detection method for toxin. The interesting proposal for the biosynthesis and the structure activity, and the detection method for toxin are outlined in this review.

Journal

  • Journal of the Pharmaceutical Society of Japan

    Journal of the Pharmaceutical Society of Japan 120(10), 825-837, 2000-10-01

    The Pharmaceutical Society of Japan

References:  36

Cited by:  1

Codes

  • NII Article ID (NAID)
    110003648867
  • NII NACSIS-CAT ID (NCID)
    AN00284903
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    00316903
  • NDL Article ID
    5504592
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z19-411
  • Data Source
    CJP  CJPref  NDL  NII-ELS 
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