食細胞を活性化させる植物性成分の探索 : フラボノイドによるTNF産生誘導

• 國實 秀和

• 上田 浩史

• 山崎 正利

書誌事項

タイトル別名

• Screening of Phagocyte Activators in Plants : Enhancement of TNF Production by Flavonoids
• ショクサイボウ オ カッセイカサセル ショクブツセイ セイブン ノ タンサク

抄録

The tumor necrosis factor (TNF) was first discovered as a substance that induced necrosis of transplanted tumors. Recently, TNF has been recognized as an important and endogenous mediator in host defense mechanisms. To prove the fact that plant foods contain substances which activate the host defense mechanisms, we first examined if the administration of flavonoids could induce TNF production in mice. Some selected flavonoids such as naringin, apiin, poncirin and rutin were shown to amplify TNF release from murine macrophages in vivo in response to OK-432 as a second stimulus. However, their aglycone forms were not effective. The differences in the saccharide-chain of flavonoids induced the variety of TNF production.

収録刊行物

• 薬学雑誌

  薬学雑誌 115 (9), 749-755, 1995

  公益社団法人 日本薬学会

キーワード

• flavonoid
• naringin
• apiin
• tumor necrosis factor
• phagocyte

詳細情報

• CRID: 1390001206155060992
• NII論文ID: 110003648988
• NII書誌ID: AN00284903
• DOI: 10.1248/yakushi1947.115.9_749
• ISSN: 13475231
• ISSN: 00316903
• ISSN: http://id.crossref.org/issn/00316903
• NDL書誌ID: 3633241
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I3633241
• Web Site: https://www.jstage.jst.go.jp/article/yakushi1947/115/9/115_9_749/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1996083709
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可