市販の大麻種子中のカンナビノイドの定量とその薬毒理作用  [in Japanese] Quantitative Analysis and Pharmaco-Toxicity of Cannabinoids in Commercially Available Cannabis Seeds  [in Japanese]

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Author(s)

Abstract

△<SUP>9</SUP>-Tetrahydrocannabinol (△<SUP>9</SUP>-THC), cannabinol, cannabidiol and cannabichromene were detected in commercially available cannabis seeds by silica gel TLC and gas chromatography. These cannabinoids existed in rather high content (0.10-2.02mg/100g of seeds) in the feed for birds, especially bracts (82.3-441mg/100g). When the suspension prepared from the benzene washing solution of cannabis seeds, BenW, was administered at a dose of 3mg/kg corresponding to △<SUP>9</SUP>-THC into a mouse, i.v., BenW caused hypothermia, catalepsy, pentobarbital-induced sleep prolongation and suppression of locomotor activity. These pharmacological activities of BenW were significantly higher than those of △<SUP>9</SUP>-THC (3mg/kg, i.v.). These results may indicate the necessity to reconsider the present regulations on marihuana.

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 118(9), 408-414, 1998-09-01

    The Pharmaceutical Society of Japan

References:  15

Codes

  • NII Article ID (NAID)
    110003649170
  • NII NACSIS-CAT ID (NCID)
    AN00284903
  • Text Lang
    JPN
  • Article Type
    ART
  • ISSN
    00316903
  • NDL Article ID
    4551447
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z19-411
  • Data Source
    CJP  NDL  NII-ELS  J-STAGE 
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