葛花の薬理学的研究(第1報)葛花のアルコール代謝並びにマウス自発運動に対する影響 Pharmacological Studies on Puerariae Flos. I. The Effects of Puerariae Flos on Alcoholic Metabolism and Spontaneous Movement in Mice

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Author(s)

Abstract

In the general rule, Puerariae Flos or it's combination drugs are used in traditional medicinal system for counteraction to drinking among Japanese and Chinese therapy. One of such drugs is Kakkakaiseito. Here we report the results of investigation on some pharmacological actions including alcoholic metabolism. The experiments were carried out to confirm its actual effect on alcohol, acetaldehyde and ketone body metabolism in the blood and the alteration of behaviour pattern of mice. Drugs used in this study were methanolic extract (PF-ME), isoflavonoid fraction (PF-IF) and triterpenoid saponin fraction (PF-SP) isolated from Puerariae Flos. Each drug was orally administrated to mice. These results were shown as follows : the concentrations of blood alcohol and acetaldehyde decreased more after the treatment with PF-IF (800 mg/kg) than those of the control group. This fact was evidenced remarkable effects with area under the blood concentration-time curve, mean residence time, and variance residence time and values on the moment analysis. However, a reduction effect was not recognized by the treatment with PF-SP (1000 mg/kg). Moreover, PF-ME and PF-IF suppressed the increment of spontaneous movement induced by alcohol administration, whereas PF-SP did not prevent the decrease in the increment caused by alcohol administration. These results support the basis that Puerariae Flos or its combination drugs is used in a traditional medicinal system for counteraction to drinking. However, further investigation is necessary.

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 109(6), 424-431, 1989

    The Pharmaceutical Society of Japan

Cited by:  12

Codes

  • NII Article ID (NAID)
    110003649907
  • NII NACSIS-CAT ID (NCID)
    AN00284903
  • Text Lang
    UNK
  • Article Type
    Journal Article
  • ISSN
    0031-6903
  • NDL Article ID
    3251453
  • NDL Source Classification
    SD0(薬学)
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z19-411
  • Data Source
    CJPref  NDL  NII-ELS  J-STAGE 
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