葛花の薬理学的研究(第2報)アルコール誘発性の代謝異常並びに実験的肝障害に対する葛花の影響 Pharmacological Studies on Puerariae Flos. II. The Effects of Puerariae Flos on Alcohol-Induced Unusual Metabolism and Experimental Liver Injury in Mice

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Abstract

The present study was designed to examine the effects of methanolic extract (PE-ME), isoflavonoid fraction (PF-IF), triterpenoid saponin fraction (PF-SP) and N-acyl-N<SUB>1</SUB>-glucosyl-tryptophan (PF-P) isolated from puerariae flos on alcohol-induced unusual metabolism (as for glucose (BG), triglyceride (TG), and urea nitrogen (BUN) level in blood) and experimental liver injury (model : CCl<SUB>4</SUB>-and high fatty food induced) in mice. These alcohol-induced increasing responses were inhibited by the extracted and refined substances from puerariae flos. In short, PF-ME (4500 mg/kg) and PF-P (400 mg/kg) inhibited an increase in BG level induced by alcohol, whereas PF-IF (1000 mg/kg) and PF-SP (1000 mg/kg) did not. Similary, PF-ME and PF-SP inhibited an increase in TG induced by alcohol, whereas PF-IF did not. In addition, PF-IF and PF-SP inhibited increasing BUN level. Still more, PF-IF and PF-SP significantly inhibited an increase in gulutamate oxalacetate transaminase or gulutamate pyruvate transaminase level induced by high-fatty food and CCl<SUB>4</SUB> in control animals. Especially PF-IF (250 mg/kg) administration showed a remarkable effect (inhibition : 76.3%) in control animals. These results suggested that puerariae flos or its combination drugs may be a useful drug as a traditional medicinal system for counteraction to drinking.

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 110(8), 604-611, 1990

    The Pharmaceutical Society of Japan

Cited by:  14

Codes

  • NII Article ID (NAID)
    110003650046
  • NII NACSIS-CAT ID (NCID)
    AN00284903
  • Text Lang
    UNK
  • Article Type
    Journal Article
  • ISSN
    0031-6903
  • NDL Article ID
    3685268
  • NDL Source Classification
    SD0(薬学)
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z19-411
  • Data Source
    CJPref  NDL  NII-ELS  J-STAGE 
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