シクロデキストリンComplexの製剤への応用

書誌事項

タイトル別名
  • Pharmaceutical Applications of Cyclodextrin Complexations
  • シクロデキストリン Complex ノ セイザイ エ ノ オウヨウ
  • Pharmaaceutical application of cyclodextrin complexations

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抄録

Cyclodextrins are homologous series of cyclic oligosaccharides consisting of glucose units joined by α-1, 4 linkages. One of the important characteristics of cyclodextrins is the formation of inclusion complexes with various guest molecules in solid phase and in solution, in which the guest molecules are included in the relatively hydrophobic cavity of cyclodextrins. The present review is mainly concerned with the possible utilities of cyclodextrins in pharmaceutical fields. A number of examples such as improvements of solubility, chemical stability, bioavailability, etc. are presented. These informations will provide a rational basis for design of formulation and a means for improving efficacy of drug activity.

収録刊行物

  • 薬学雑誌

    薬学雑誌 101 (10), 857-873, 1981

    公益社団法人 日本薬学会

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