Prevention of Adsorption of Insulin on Containers

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  • インシュリンの容器への吸着防止について
  • インシュリン ノ ヨウキ エ ノ キュウチャク ボウシ ニ ツイテ

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Abstract

Adsorption of insulin was studied by using glass ampule, silicone-coated glass ampule and polyvinylchloride tube. Insulin was well adsorbed onto silicone-coated glass ampule and polyvinylchloride tube. It is suggested that the preferential adsorption of insulin on silicone-coated glass ampule and polyvinylchloride tube is probably the result of hydrophobic interaction between hydrophobic moieties of insulin molecule and hydrophobic portion of these containers. Phenomenon of this adsorption is assumed to be competitive interaction between hydrophobic moieties of insulin molecule and some substances on hydrophobic portion of containers. I have tried to prevent the adsorption of insulin on containers by adding various kinds of surface-active substance which have hydrophobic group in molecule and rich solubility in water. In conclusion, adsorption of insulin can be remarkably decreased by the slight addition of surface-active substance.

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 104 (3), 311-315, 1984

    The Pharmaceutical Society of Japan

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