癌化学療法剤による, 食細胞の殺癌効果の誘導と増強

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タイトル別名
  • Induction and Potentiation of Phagocyte-Mediated Tumor Lysis by Chemotherapeutic Drugs for Cancer
  • ガン カガク リョウホウザイ ニ ヨル,ショクサイボウ ノ サツ ガン コウカ

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抄録

The present study shows that some selected anti-cancer drugs induce tumor lysis in vitro in cooperation with phagocytic cells (drug-dependent cellular cytotoxicity ; DDCC) and that chemotherapeutic drugs augment the mediator-dependent killing activity of macrophages. Tumor cells pretreated with the drugs were susceptible to phagocytemediated killing. Tumor necrosis serum can also cooperate with some drugs in killing tumor cells. Moreover, some selected drugs can induce cytotoxic macrophages and the quantitative changes of phagocytes such as polymorphonuclear leukocytes. These results suggest that some anti-cancer drugs have the activities of inactivation of tumor cells and/or activation of host cells. Thus, tumor cells may be killed effectively in vivo by anti-cancer drugs through these mechanisms.

収録刊行物

  • 薬学雑誌

    薬学雑誌 104 (7), 769-774, 1984

    公益社団法人 日本薬学会

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