書誌事項
- タイトル別名
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- Studies on Metabolism of Bromazepam. I. Isolation and Identification of the Metabolites of Bromazepam in Urine
- Bromazepamの代謝に関する研究-1-尿中代謝産物の単離と同定
- Bromazepam ノ タイシャ ニ カンスル ケンキュウ 1 ニョウ チュウ タイシャ サンブツ ノ タンリ ト ドウテイ
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Besides the unchanged drug, two major metabolites were found from the urine of animals that received orally high doses of bromazepam, 7-bromo-1, 3-dihydro-5-(2-pyridyl)-2H-1, 4-benzodiazepin-2-one. The metabolites were purified by column chromatography on silica gel and recrystallization. From the spectral and elemental analysis data, the structure of these metabolites were identified as 2-amino-5-bromobenzoylpyridine and assumed to be 2-amino-5-bromo-3-hydroxybenzoylpyridine, the latter being excreted as its glucuronide in the urine. It may be concluded that bromazepam after opening of the diazepine ring undergoes a process of hydroxylation.
収録刊行物
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- 薬学雑誌
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薬学雑誌 92 (10), 1237-1241, 1972
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001206217180544
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- NII論文ID
- 110003651143
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- NII書誌ID
- AN00284903
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- ISSN
- 13475231
- 00316903
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- NDL書誌ID
- 7649465
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- データソース種別
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- JaLC
- NDL
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- 抄録ライセンスフラグ
- 使用不可