柴胡の薬理学的研究-4-Crude saikosides,Saikogenin Aおよび Syrupy residueの薬理作用 Pharmacological studies on Bupleurum falcatum L. IV. Some pharmacological effects of crude saikosides, saikogenin A and syrupy residue

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Crude saikosides did not affect the LD_<50> value of sodium hexobarbital in mice. It also exerted a protective effect on the pylorus-ligated ulcer of the rat with inhibiting gastric secretion. The cure of chronic ulcer produced by the injection of dilute acetic acid into the rat gastric wall was promoted by crude saikosides. Saikogenin A showed a potent effect of decreasing spontaneous motor activities of the mice treated with methamohetamine hydrochloride. It had a significant antitussive, hypothermic, and antipyretic effect, and inhibition of acetic acid-induced writhing responses. In addition, salikogenin A strongly reduced a carrageenin-induced rat paw edema, without any local irritaition by topical application. On the contrary, only analgesic effect was found in the syrupy residue. The significance of these pharmacological results was discussed.

収録刊行物

  • 薬学雑誌

    薬学雑誌 93(12), 1660-1667, 1973-12

    公益社団法人日本薬学会

被引用文献:  8件中 1-8件 を表示

各種コード

  • NII論文ID(NAID)
    110003651456
  • NII書誌ID(NCID)
    AN00284903
  • 本文言語コード
    JPN
  • 資料種別
    雑誌論文
  • ISSN
    00316903
  • NDL 記事登録ID
    7649831
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z19-411
  • データ提供元
    CJP引用  NDL  NII-ELS 
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