メバロン酸代謝拮抗物質の研究(第1報)アンヒドロメバロン酸の微生物活性について

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タイトル別名
  • Studies on the Antimetabolites of Mevalonic Acid.I. Microbiological Activities of 2, 3-Anhydro-mevalonic Acid
  • メバロン酸代謝拮抗物質の研究-1-アンヒドロメバロン酸の微生物活性について
  • メバロンサン タイシャ キッコウ ブッシツ ノ ケンキュウ 1 アンヒドロメバ

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抄録

Examinations were made on the action of anhydromevalonic acid lactone, which inhibits incorporation of mevalonic acid into cholesterol in the cell-free system of rat liver, on microorganisms was studied. Microorganisms examined were mevalonic acid-requiring Lactobacillus acidphilus ATCC 4963 and L. heterohiochii H-1, and Saccharomyces cerevisiae and S. carlsbergensis ATCC 9080 which do not require mevalonic acid and have the ability to synthesize sterol. In the presence of 0.1 μg/ml of mevalonic acid, L. acidophilus required ca. 15 mg/ml of anhydromevalonic acid lactone for 50% suppression and 25 mg/ml for 100% suppression. In the presence of 1.0 or 4.0 μg/ml of mevalonic acid, L. heterohiochii required 0.5 and 20 mg/ml, respectively, of anhydromevalonic acid lactone. In the presence of 15 and 20 mg/ml of anhydromevalonic acid lactone the growth of S. cerevisiae and S. carlsbergensis was completely inhibited. However, there was hardly any effect on the sterol content per unit cell weight.

収録刊行物

  • 薬学雑誌

    薬学雑誌 96 (6), 732-736, 1976

    公益社団法人 日本薬学会

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