打錠工程における薬剤の粘塑性挙動

書誌事項

タイトル別名
  • Visco-plastic Behavior of Powder in the Process of Dynamic Compression
  • ダジョウ コウテイ ニ オケル ヤクザイ ノ ネンソセイ キョドウ

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抄録

We established a new method to quantitatively evaluate two types of consumed energies resulting from plastic deformation (Ep) and viscosity (Ev) of sample. To evaluate a new parameter (ΔE/ΔV), the tabletting velocity (V) dependence of Ev, was determined. We found that the total consumed energy (Et) consists of Ep and Ev, and the tabletting velocity dependence of Et is expressed as a simple first order equation, Et=a·V+b, where a and b mean ΔE/ΔV and Et, respectively. The parameter ΔE/ΔV is considered to express the grade of negative contribution of sample viscosity to the tabletting process.

収録刊行物

  • 薬学雑誌

    薬学雑誌 99 (4), 325-328, 1979

    公益社団法人 日本薬学会

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