高尾(東京都)産トリカブト塩基成分について On the Alkaloids of Aconitum japonicum THUNB. collected at Mt. Takao (Tokyo)
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Reinvestigation of the alkaloidal constituents of Aconitum japonicum THUNB. of Mt. Takao (Tokyo) was made. In addition to the reported constituents, i.e. isohypognavine, delcosine and dehydrodelcosine, two known compounds, isotalatizidine and condelphine, were isolated. Furthermore, five new bases, i.e. 11-acetylisohypognavine, diacetylisohypognavine, 14-acetyltalatizamine, takaosamine and takaonine, were isolated and their structures were elucidated. Takaosamine was proved to be 18-O-demethyldelcosine from the spectroscopic study on the parent material and the acetyl derivatives, and from the chemical correlation with known diterpene alkaloids, gigactonine and delsoline. The structure of takaonine was deduced to be 2, 3-dehydro-14-dehydrodelcosine on the basis of <SUP>13</SUP>C-nuclear magnetic resonance spectral evidence and the derivation to the known diterpene alkaloid, delcosine, by catalytic hydrogenation.
- YAKUGAKU ZASSHI
YAKUGAKU ZASSHI 99(6), 647-656, 1979
The Pharmaceutical Society of Japan