Inhibition of Urease Activity by Dipeptidyl Hydroxamic Acids

  • 小竹 慎二郎
    Research Institute, Fuji Chemical Industries, Ltd.,
  • 中橋 和明
    Research Institute, Fuji Chemical Industries, Ltd.,
  • 森川 忠則
    Research Institute, Fuji Chemical Industries, Ltd.,
  • 竹部 幸子
    Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
  • 小橋 恭一
    Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University

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抄録

A series of dipeptidyl hydroxamic acids (H-X-Gly-NHOH : X=amino acid residues) was synthesized, and the inhibitory activity against Jack bean and Proteus mirabilis ureases [EC 3.5.1.5] was examined. A number of H-X-Gly-NHOH inhibited Jack bean urease with an I_<50> of the order of 10^<-6>M and inhibited Proteus mirabilis urease with an I_<50> of the order of 10^<-5>M. The inhibition against Jack bean urease was more potent than that with the corresponding aminoacyl hydroxamic acids (H-X-NHOH).

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詳細情報 詳細情報について

  • CRID
    1574231877202891136
  • NII論文ID
    110003654911
  • NII書誌ID
    AA00602100
  • ISSN
    00092363
  • 本文言語コード
    en
  • データソース種別
    • CiNii Articles

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