バイオセルトレーサーを用いた生薬アセトン抽出物中の抗真菌活性物質の高感度スクリーニング

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タイトル別名
  • Sensitive Screening of Antifungal Compounds from Acetone Extracts of Medicinal Plants with a Bio-Cell Tracer
  • バイオセル トレーサー オ モチイタ ショウヤク アセトン チュウシュツブツ チュウ ノ コウ シンキン カッセイ ブッシツ ノ コウカンド スクリーニング

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抄録

Antifungal activity of medicinal plants against Aspergillus niger was evaluated using Bio-Cell Tracer (BCT). By this system enabled the real time determination of hyphal growth rate could be done in the presence or absence of Chinese herbal extracts. Of the 41 herbal extracts with 60% acetone extracts tested by the present method, 26 were found to contain active components against A. niger hyphal growth. In contrast, by conventional methods, no active component was detected from every herbal extract except 3 herbal extracts. From the extract of Anemarrhena asphodeloides, one of active components was isolated and its structure determined by NMR, UV, and mass spectroscopy. The compound was identified as broussonin A (2-3-(4-hydroxyphenyl)propyl)-5-methoxy-phenol) which was formerly reported as a phytoalexin of Broussonetia papyrifera VENT.

収録刊行物

  • 薬学雑誌

    薬学雑誌 119 (12), 964-971, 1999

    公益社団法人 日本薬学会

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