SYNTHESIS AND PHARMACOLOGICAL PROPERTIES OF MORPHINE CONGENERS HAVING PENDANT CROWN ETHER AS AN OPIOID RECEPTOR PROBE

• 藤井 郁雄

  Institute of Synthetic Organic Chemistry, Faculty of Pharmaceutical Sciences, Kyushu University

• 十亀 弘子

  Institute of Synthetic Organic Chemistry, Faculty of Pharmaceutical Sciences, Kyushu University

• 兼松 顕

  Institute of Synthetic Organic Chemistry, Faculty of Pharmaceutical Sciences, Kyushu University

抄録

Morphine congeners (5a, 5b, and 10) with pendant benzo[15-crown-5]crown ether at C-6 were synthesized. Their pharmacological properties were evaluated on ^3H-naloxone binding, analgestic, and antitussive tests.

収録刊行物

• Chemical & pharmaceutical bulletin

  Chemical & pharmaceutical bulletin 34 (10), 4439-4442, 1986-10-25

  公益社団法人日本薬学会

キーワード

• crowned morphine
• benzo[15-crown-5]crown ether
• opioid receptor probe
• sodium effect
• ^3H-naloxone binding test
• analgesic test
• antitussive test

詳細情報

• CRID: 1572543027316339328
• NII論文ID: 110003662790
• NII書誌ID: AA00602100
• ISSN: 00092363
• Web Site: https://search.jamas.or.jp/link/ui/1987113702
• 本文言語コード: en
• データソース種別:
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