Novel Benzoxazole 2,4-Thiazolidinediones as Potent Hypoglycemic Agents. Synthesis and Structure-Activity Relationships.

• ARAKAWA Kenji

• INAMASU Masanori

• MATSUMOTO Mamoru

• OKUMURA Kunihito

• YASUDA Kosuke

• AKATSUKA Hidenori

• KAWANAMI Saburo

• WATANABE Akishige

• HOMMA Koichi

• SAIGA Yutaka

• OZEKI Masakatsu

• IIJIMA Ikuo

書誌事項

タイトル別名

• Novel Benzoxazole 2 4 Thiazolidinedione

抄録

A new series of benzoxazole 2, 4-thiazolidinediones was synthesized and evaluated for hypoglycemic activity in genetically obese and diabetic yellow KK mice. 2-Arymethyl- and 2-(heteroarhylmethyl)benzoxazole derivatives showed far more potent activity than known 2, 4-thiazolidinedione derivatives such as ciglitazone, troglitazone and pioglitazone. A facile synthesis of benzoxazole 2, 4-thiazolidinediones was also established using aminophenol 2, 4-thiazolidinedione (11) as a key intermediate. Details of synthesis and structure-activity relationships for this series are described.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 45 (12), 1984-1993, 1997

  公益社団法人 日本薬学会

キーワード

• hypoglycemic agent
• NIDDM
• insulin resistance
• benzoxazole 2, 4-thiazolidinedione
• structure-activity relationship

詳細情報

• CRID: 1390001204161844608
• NII論文ID: 130003773670
• NII論文ID: 110003662829
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.45.1984
• ISSN: 13475223
• ISSN: 00092363
• NDL書誌ID: 4371067
• PubMed: 9433768
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4371067
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/45/12/45_12_1984/_pdf
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可