Preparation of Useful Synthetic Intermediates of Taxol Analogs, Cyclooctenone Derivatives.

• YAMADA Koji

• TOZAWA Takashi

• SAITOH Katsuyuki

• MUKAIYAMA Teruaki

Bibliographic Information

Other Title

• Preparation of Useful Synthetic Interme

Abstract

Stereoselective syntheses of ω-(α-bromoketo) octanals and nonanal with oxygenated functions and formation of the corresponding eight-membered carbocyclic aldols by subsequent samarium(II)-mediated cyclization are demonstrated. Cyclooctenones deoxygenated at the C2 or C10 position in the taxane framework are prepared by dehydration of the above aldols.

Journal

• Chemical and Pharmaceutical Bulletin

  Chemical and Pharmaceutical Bulletin 45 (12), 2113-2115, 1997

  The Pharmaceutical Society of Japan

Keywords

• cyclooctenone
• samarium(II) iodide
• ω-(α-bromoketo aldehyde
• deoxygenated taxane framework

Details

• CRID: 1390282679137319040
• NII Article ID: 130003773661
• NII Article ID: 110003662852
• NII Book ID: AA00602100
• DOI: 10.1248/cpb.45.2113
• ISSN: 13475223
• ISSN: 00092363
• NDL BIB ID: 4371090
• PubMed: 9433783
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4371090
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/45/12/45_12_2113/_pdf
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed