Reduction of Heterocyclic Compounds. II. Reduction of Heterocyclic Compounds with Sodium Borohydride-Transition Metal Salt Systems
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The reduction of heterocyclic compounds with the sodium borohydride-transition metal salt system was investigated. Among transition metal salts examined in this system, the sodium borohydride-nickelous chloride system was found to exhibit the strongest reducing activity. Quinoline, isoquinoline, quinoxaline and their derivatives were reduced with this system to give the corresponding tetrahydro derivatives.
- Chemical & pharmaceutical bulletin
Chemical & pharmaceutical bulletin 32(6), 2421-2425, 1984-06-25
The Pharmaceutical Society of Japan