Potassium Bromate-Induced Hyperuricemia Stimulates Acute Kidney Damage and Oxidative Stress

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  • Watanabe Satoshi
    Department of Health Chemistry, Faculty of Pharmaceutical Sciences, Hoshi University
  • Tajima Yukie
    Department of Health Chemistry, Faculty of Pharmaceutical Sciences, Hoshi University
  • Yamaguchi Tomoko
    Department of Health Chemistry, Faculty of Pharmaceutical Sciences, Hoshi University
  • Fukui Tetsuya
    Department of Health Chemistry, Faculty of Pharmaceutical Sciences, Hoshi University

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Acute exposure of mice to potassium bromate (KBrO3), which is a major disinfection by-product of ozonation and/or chlorination of bromide-containing raw waters, causes serious kidney failure and neuropathological disorders. We observed significant elevations of serum uric acid levels and xanthine oxidase activity by KBrO3 administration (1.2 mmol/kg) with elevating relative kidney weight, serum creatinine levels and renal oxidative stress. Therefore, allopurinol was administered to KBrO3-treated mice to examine if the elevation of blood uric acid levels causes acute kidney damage and renal oxidative stress. These KBrO3-induced elevations were significantly prevented by intraperitoneal administration of allopurinol (10 or 50 mg/kg) and significant correlation between kidney damage and uric acid levels was observed. Reduction of catalase activity in the kidney of KBrO3-treated mice, which results in the accumulation of hydrogen peroxide, was also restored by allopurinol. There were significant correlations between catalase activity and uric acid levels or kidney damage. Furthermore, in in vitro experiment, catalase activity was reduced in the presence of physiological concentration of uric acid (approximately 0.3 mM or more). These results suggest that the reduction of catalase activity by the elevation of blood uric acid levels is a major cause of KBrO3-induced acute kidney damage. Allopurinol also suppressed KBrO3-induced increases of renal thiobarbituric acid reactive substances levels and renal protein carbonyl levels of mice. Furthermore, significant correlation between oxidative stress and blood uric acid levels was observed. Therefore, KBrO3 seems to cause hyperuricemic status which in turn brings about acute kidney damage and oxidative stress with reducing catalase activity. <br>

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