Estrogenic Potency of a Bisphenol A Metabolite on Vitellogenin Synthesis in Medaka, Oryzias latipes

• Nagae Masaki

  Faculty of Environmental Studies, Nagasaki University

• Shiroyama Ken'ichirou

  Faculty of Environmental Studies, Nagasaki University

• Inoue Mihoka

  Division of Marine Bioscience, Graduate School of Fisheries Science

• Hara Akihiko

  Division of Marine Bioscience, Graduate School of Fisheries Science

• Takao Yuji

  Faculty of Environmental Studies, Nagasaki University

• Kohra Shinya

  Faculty of Environmental Studies, Nagasaki University

• Ishibashi Yasuhiro

  Environmental Protection Center, Nagasaki University

• Tominaga Nobuaki

  Department of Chemical and Biological Engineering, Ariake National College of Technology

• Yoshihara Shin'ichi

  Department of Xenobiotic Metabolism and Molecular Toxicology, Graduate School of Biomedical Science, Hiroshima University

• Arizono Koji

  Faculty of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto

Abstract

We investigated the estrogenic activity of a bisphenol A (BPA) metabolite (4-methyl-2,4-bis(p-hydroxyphenyl)-pent-1-ene; MBP) in male medaka (Oryzias latipes) using vitellogenin (Vg, Vg1 and Vg2) as a biomarker. Male d-rR medaka were exposed to various concentrations of estradiol-17β (E₂), MBP and BPA for 3 days, and then the serum Vg concentration was measured using specific chemiluminescent immunoassays. The estimated relative estrogenic activities of MBP and BPA compared with E₂ (100%) were 1.3-1.4% and 0.00010-0.00023%, respectively. These findings indicated that MBP has about 10⁴-fold higher estrogenic potency than the parent BPA and about 1/50 that of E₂ for Vg synthesis in medaka. This is the first study to show that MBP can act as a highly potent estrogen agonist in living organisms. <br>

Journal

• Journal of Health Science

  Journal of Health Science 51 (1), 93-95, 2005

  The Pharmaceutical Society of Japan

Keywords

• bisphenol A metabolite
• estrogenic activity
• vitellogenin
• 4-methyl-2,4-bis(<I>p</I>-hydroxyphenyl)-pent-1-ene
• medaka

Details

• CRID: 1390001204498005760
• NII Article ID: 110003666038
• NII Book ID: AA11316464
• DOI: 10.1248/jhs.51.93
• ISSN: 13475207
• ISSN: 13449702
• HANDLE: 10069/8370
• NDL BIB ID: 7233433
• Web Site: https://nagasaki-u.repo.nii.ac.jp/records/23155
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7233433
• Web Site: http://www.jstage.jst.go.jp/article/jhs/51/1/51_1_93/_pdf
• Text Lang: en
• Data Source:
  • JaLC
  • IRDB
  • NDL
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed