PACAP遺伝子欠損マウスの脳機能変化

• 新谷 紀人

  大阪大学大学院薬学研究科神経薬理学分野

書誌事項

タイトル別名

• Mice Lacking PACAP: A Minireview Focussing on the Brain Function
• PACAP イデンシ ケッソン マウス ノ ノウ キノウ ヘンカ

抄録

  Pituitary adenylate cyclase-activating polypeptide (PACAP) is a member of the vasoactive intestinal peptide (VIP)/ secretin/ glucagon superfamily and functions as a hormone, neurohormone, and neurotransmitter in the central nervous system as well as in several peripheral tissues. Recently, several groups including ours have independently produced lines of mice lacking PACAP (PACAP^-/-). These mutant mice have not only led to a better understanding of the physiologic roles of endogenous PACAP, but have also revealed some unexpected roles of PACAP. In this paper, phenotypic changes in several brain functions in PACAP^-/- mice, including light-induced phase-resetting of the circadian activity rhythm, hippocampal long-term potentiation, and psychomotor behaviors, are reviewed based on the results obtained in our laboratory.<br>

収録刊行物

• 薬学雑誌

  薬学雑誌 124 (10), 667-671, 2004-10-01

  公益社団法人 日本薬学会

キーワード

• PACAP
• neuropeptide
• knockout mice
• psychomotor behavior
• circadian rhythm
• long-term potentiation

詳細情報

• CRID: 1390001206128434688
• NII論文ID: 110003666124
• NII書誌ID: AN00284903
• DOI: 10.1248/yakushi.124.667
• ISSN: 13475231
• ISSN: 00316903
• NDL書誌ID: 7110491
• PubMed: 15467274
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7110491
• Web Site: https://www.jstage.jst.go.jp/article/yakushi/124/10/124_10_667/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2005019140
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可