Triterpenoid from Styrax japonica SIEB. et ZUCC, and Its Effects on the Expression of Matrix Metalloproteinases-1 and Type 1 Procollagen Caused by Ultraviolet Irradiated Cultured Primary Human Skin Fibroblasts

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  • Moon Hyung-In
    Department of Dermatology, Seoul National University College of Medicine, Korea Institute of Dermatological Science, Seoul National University, Korea
  • Kim Mi-Ran
    College of Pharmacy, Chosun University
  • Woo Eun-Ran
    College of Pharmacy, Chosun University
  • Chung Jin Ho
    Department of Dermatology, Seoul National University College of Medicine, Korea Institute of Dermatological Science, Seoul National University, Korea

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Long term and repeated exposure of ultraviolet light on the skin often induces chronic skin diseases such as skin cancer as well as photoaging, and the mechanisms of these skin damages are closely associated with up-regulation of matrix metalloproteinase's (MMPs) activities. The methylene chloride soluble fraction of methanol extract from the stems of Styrax japonica. (Styracaceae) showed significant MMP-1 inhibition in primary human skin fibroblasts cause by ultraviolet irradiation. Four triterpenoids were isolated by column chromatography. Among them, Erythrodiol-3-acetate reduced of MMP-1 and induced of type 1 procollagen at the protein levels in a dose-dependent manner.

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