Alteration of Leptin-Induced STAT3 Activation in the Brain of Senescence-Accelerated Mouse (SAM) P8
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- Hosoi Toru
- Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University Department of Pharmacotherapy, Graduate School of Biomedical Sciences, Hiroshima University
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- Okuma Yasunobu
- Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University Department of Pharmacology, Faculty of Pharmaceutical Sciences, Chiba Institute of Science
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- Ono Atsushi
- Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University
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- Nomura Yasuyuki
- Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University Daiichi University, College of Pharmaceutical Sciences
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We used senescence-accelerated mouse prone 8 (SAMP8), a useful model of accelerated aging, to investigate the responsiveness to leptin with aging. The state of leptin-induced STAT3 phosphorylation in the hypothalamus was found to be higher in SAMP8 than in SAMR1, a control mouse showing normal aging, at 14—18 months of age but not at 2 months of age. Moreover, leptin receptor Ob-Rb expression in the hypothalamus was up-regulated in SAMP8. The results indicate that leptin sensitivity increases with aging in the SAM mouse brain.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 28 (8), 1514-1516, 2005
公益社団法人 日本薬学会
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詳細情報
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- CRID
- 1390001204627668864
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- NII論文ID
- 110003666457
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- NII書誌ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 7372787
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- PubMed
- 16079504
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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- PubMed
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- 使用不可