Simultaneous Analysis of Endocrine Disruptors, 4-Alkylphenol and Bisphenol A, Contained in Synthetic Resin Products Used for Drug Containers and Household Utensils

• Sakurai Katsumi

  Yokohama City Institute of Health

• Sugaya Naeko

  Yokohama City Institute of Health

• Nakagawa Tomoo

  Yokohama City Institute of Health

• Uchiyama Taketo

  College of Pharmacy, Nihon University

• Fujimoto Yasuo

  College of Humanities and Sciences, Nihon University

• Takahashi Kunio

  Meiji Pharmaceutical University

Abstract

The chemical structures of individual isomers present in a mixture of 4-nonylphenol have recently been clarified, and differences in estrogen activity due to differences in the structure have been reported. Considering the importance of investigations of the chemical structure of 4-nonylphenol contained in commonly used synthetic resin products, we investigated an analytical method of individual isomers of 4-nonylphenol using positive chemical ionization-gas chromatography/mass spectrometry (PCI-GC/MS). Furthermore, we established a highly sensitive simultaneous analysis method using PCI-GC/MS [selected ion monitoring (SIM)], in which 4-alkylphenol and bisphenol A were extracted using a simple dissolution method without pretreatment such as solid-phase extraction and derivatized by trimethylsilylation. <br>

Journal

• Journal of Health Science

  Journal of Health Science 51 (5), 538-548, 2005

  The Pharmaceutical Society of Japan

Keywords

• alkylphenol
• bisphenol A
• positive chemical ionization-GC/MS
• chemical endocrine disruptor
• drug container
• household utensil

Details

• CRID: 1390001204498189440
• NII Article ID: 110003666525
• NII Book ID: AA11316464
• DOI: 10.1248/jhs.51.538
• ISSN: 13475207
• ISSN: 13449702
• NDL BIB ID: 7452713
• Web Site: http://id.ndl.go.jp/bib/7452713
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7452713
• Web Site: http://www.jstage.jst.go.jp/article/jhs/51/5/51_5_538/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2006309170
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed