骨組織再構築のための生体材料　高分子電解質錯体と骨芽細胞との相互作用

DOI Web Site 被引用文献13件 参考文献36件

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  • Biomaterials for the Reconstruction of Osseous Tissue. Interactions between Various Types of Polyelectrolyte Complex and Osteoblast.
  • Interactions between Various Types of Polyelectrolyte Complex and Osteoblast
  • 高分子電解質錯体と骨芽細胞との相互作用

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The purpose of this study was to assess whether polyelectrolyte complexes (PECs) produced by the combination of oppositely charged polyelectrolyte aqueous polycations and polyanions were suitable as new biomaterials for the reconstruction of osseous tissue (carrier of BMP).<BR>The 90 types of PEC, produced by combining 6 types of polycations with 15 types of polyanions, were coated on cell culture dishes to investigate the interactions between various types of PEC and osteogenic cell line MC 3 T 3-E 1 cells at the cellular level, and emphasis was placed on cell adhesion, proliferation, and differentiation. Among the 90 types of PEC studied, 18 were equal to or nearly equal to those on non-PECcoated control dishes with respect to cell adhesion, proliferation, and ALP activity. Properties and surface charge associated with differences in the functional groups of the polymers appeared to be important factors in cell adhesion, proliferation, and differentiation.<BR>These results suggested that the 18 types of PEC that showed good cell adhesion, proliferation, and differentiation are carriers that have no negative effect on the physiological functions of cells; these PECs are promising as biomaterials for the reconstruction of osseous tissue (carrier of BMP).

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