Properties of the Tumor Suppressor Gene Brca2 in the Cat
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- OONUMA Toshina
- Laboratory of Veterinary Physiolosy, Faculty of Agriculture, Iwate University
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- MORIMATSU Masami
- Laboratory of Veterinary Physiolosy, Faculty of Agriculture, Iwate University
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- OCHIAI Kazuhiko
- Laboratory of Veterinary Physiolosy, Faculty of Agriculture, Iwate University
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- SYUTO Bunei
- Laboratory of Veterinary Physiolosy, Faculty of Agriculture, Iwate University
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Mammary tumors are common in cats. As mutations in human Brca2 confer an increased risk of breast cancer, the full-length cDNA of the feline homologue of Brca2 was sequenced to obtain a basis for studying the relationship between its function and susceptibility to mammary tumors. The feline Brca2 cDNA is 10 kb long, and encodes 3,371 amino acids. The amino acid sequence of feline Brca2 shares low homology with the Brca2 of other mammals, e.g., 53% homology with the murine protein. Analysis of the expression pattern of the feline Brca2 gene revealed that, as previously reported for other mammals, it is transcribed in various tissues, including the mammary gland.<br>
収録刊行物
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- The Journal of Veterinary Medical Science
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The Journal of Veterinary Medical Science 65 (10), 1123-1126, 2003
公益社団法人 日本獣医学会
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詳細情報 詳細情報について
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- CRID
- 1390001206427352448
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- NII論文ID
- 110003886138
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- NII書誌ID
- AA10796138
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- ISSN
- 13477439
- 09167250
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- NDL書誌ID
- 6743768
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- PubMed
- 14600353
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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- PubMed
- CiNii Articles
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- 使用不可