Expression of estrogen receptor α and β in the uterus and vagina of immature rats treated with 17-ethinyl estradiol

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  • KANG Jin Seok
    National Institute of Toxicology Research, Korea Food and Drug Administration
  • LEE Beom Jun
    College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University
  • AHN Byeongwoo
    College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University
  • KIM Dae Joong
    College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University
  • NAM Sang Yoon
    College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University
  • YUN Young Won
    College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University
  • NAM Ki Taek
    National Institute of Toxicology Research, Korea Food and Drug Administration
  • CHOI Mina
    National Institute of Toxicology Research, Korea Food and Drug Administration
  • KIM Hyung Sik
    National Institute of Toxicology Research, Korea Food and Drug Administration
  • JANG Dong Deuk
    National Institute of Toxicology Research, Korea Food and Drug Administration
  • LEE Yong Soon
    College of Veterinary Medicine, Seoul National University
  • YANG Ki-Hwa
    National Institute of Toxicology Research, Korea Food and Drug Administration

書誌事項

タイトル別名
  • Expression of Estrogen Receptor .ALPHA. and .BETA. in the Uterus and Vagina of Immature Rats Treated with 17-Ethinyl Estradiol
  • Expression of estrogen receptor アルファ and ベータ in the uterus and vagina of immature rats treated with 17 ethinyl estradiol

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抄録

The action of estrogen on target organs has been actively studied with the discovery of estrogen receptor (ER) β. This study was carried out to examine the expression of ERα and ERβ in the uterus and the vagina of immature Sprague-Dawley rats treated with 17-ethinyl estradiol (EE). Twenty days old rats were subcutaneously treated with EE at the doses of 0 (vehicle control), 0.03, 0.3, 1.0, 3.0, and 10.0 μg/kg/day for three consecutive days. The treatment of EE at the doses of 0.3, 1.0, 3.0 and 10.0 μg/kg/day significantly increased the weights of the uterus and vagina of rats (p<0.01) and retained fluid in the uterus of rats. At the high doses of 3.0 and 10.0 μg/kg/day, the treatment of EE caused an increase in the uterine height, hypertrophy, and a decrease in the expression of ERα and ERβ in the uterine luminal and glandular epithelium. The treatment of EE at the doses of 3.0 and 10.0 μg/kg/day also caused cornification and a decrease in the expression of ERα and ERβ in the vaginal epithelium. These results suggest that the EE treatment decrease the expression of ERα and ERβ in the uterus and vagina of immature rats and that may be associated with the morphological changes such as increase in the uterine height, hypertrophy of the uterine epithelium, and cornification of the vagina.<br>

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