Immune Responses of Immunocompetent and Immunocompromised Mice Experimentally Infected with Bartonella henselae
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- KABEYA Hidenori
- Laboratory of Veterinary Public Health, Department of Veterinary Medicine, College of Bioresource Science, Nihon University
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- TSUNODA Emiko
- Laboratory of Veterinary Public Health, Department of Veterinary Medicine, College of Bioresource Science, Nihon University
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- MARUYAMA Soichi
- Laboratory of Veterinary Public Health, Department of Veterinary Medicine, College of Bioresource Science, Nihon University
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- MIKAMI Takeshi
- Laboratory of Veterinary Public Health, Department of Veterinary Medicine, College of Bioresource Science, Nihon University
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The aim of this study is to understand host immune responses in immunocompetent and immunocompromised mice against Bartonella henselae infection. BALB/c and nude (BALB/c nu/nu) mice were inoculated intraperitoneally with 108 colony forming units of B. henselae (Houston-1 strain). Blood, brain, liver, spleen, kidney and bone marrow samples were collected 0, 3, 7, 14, 21 and 28 days after infection and submitted to bacteriological, serological and genetical examinations. B. henselae was isolated only from the liver 3 days after infection. DNA of the inoculums was detected by polymerase chain reaction from blood, liver, and spleen samples collected from BALB/c and blood from nude mice 3 and 7 days after infection. No bacterial DNA was detected from both BALB/c and nude mice thereafter during 4 weeks observation periods. These results indicate that the T-cell may not participate in the effective elimination of the organisms from mice. In addition, western blot analysis revealed that the antigens of 27.3- and 31.5-kDa reacted with IgM antibodies from the blood of BALB/c and nude mice after 3 days of infection, suggesting that these antigens were recognized by thymus-independent mechanism. Furthermore the antigens were detected from the culture-supernatants of B. henselae, indicating that these antigens were secreted from the organisms.<br>
収録刊行物
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- The Journal of Veterinary Medical Science
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The Journal of Veterinary Medical Science 65 (4), 479-484, 2003
公益社団法人 日本獣医学会
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詳細情報 詳細情報について
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- CRID
- 1390001206424850304
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- NII論文ID
- 110003886198
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- NII書誌ID
- AA10796138
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- COI
- 1:CAS:528:DC%2BD3sXkt1GnsL4%3D
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- ISSN
- 13477439
- 09167250
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- NDL書誌ID
- 6567715
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- PubMed
- 12736430
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可