SIV/HIVキメラウイルスより構築されたvprベクターの性状

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  • HAGA Takeshi
    Department of Veterinary Microbiology, Miyazaki University
  • OKOBA Masashi
    Department of Veterinary Microbiology, Miyazaki University
  • YAMAZAKI Nanase
    Department of Veterinary Microbiology, Miyazaki University
  • KUMABE Shino
    Department of Veterinary Microbiology, Miyazaki University
  • SHIMIZU Yuya
    Department of Veterinary Microbiology, Miyazaki University
  • GOTO Yoshitaka
    Department of Veterinary Microbiology, Miyazaki University
  • KUWATA Takeo
    Laboratory of Viral Pathogenesis, Institute for Virus Research, Kyoto University
  • KOZYREV Iouri L.
    Laboratory of Viral Pathogenesis, Institute for Virus Research, Kyoto University
  • HAYAMI Masanori
    Laboratory of Viral Pathogenesis, Institute for Virus Research, Kyoto University
  • MIURA Tomoyuki
    Laboratory of Viral Pathogenesis, Institute for Virus Research, Kyoto University

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タイトル別名
  • Characterization of vpr Vector Constructed from Chimeric Simian and Human Immunodeficiency Virus

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Chimeric simian and human immunodeficiency viruses (SHIVs) are useful tool for investigating AIDS pathogenesis and for development of vaccine. We constructed a SHIV-vpr vector (designated as SHIV-3sj) by replacing vpr region with restriction enzyme sites. SHIV-3sj was designed to express inserted gene along with its viral replication. Five cytokine genes were inserted into SHIV-3sj, and ability of viral replication and expression of the inserted genes were examined. The short insert including RANTES and IL-5 resulted in the successful expression from SHIV-3sj, while the construct having longer genes including IL-2, IL-6 and IL-12p35 failed to become replication competent. These results suggest that the length of the insert is an important factor for the replication ability of SHIV-3sj vector.<br>

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