SIV/HIVキメラウイルスより構築されたvprベクターの性状
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- HAGA Takeshi
- Department of Veterinary Microbiology, Miyazaki University
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- OKOBA Masashi
- Department of Veterinary Microbiology, Miyazaki University
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- YAMAZAKI Nanase
- Department of Veterinary Microbiology, Miyazaki University
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- KUMABE Shino
- Department of Veterinary Microbiology, Miyazaki University
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- SHIMIZU Yuya
- Department of Veterinary Microbiology, Miyazaki University
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- GOTO Yoshitaka
- Department of Veterinary Microbiology, Miyazaki University
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- KUWATA Takeo
- Laboratory of Viral Pathogenesis, Institute for Virus Research, Kyoto University
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- KOZYREV Iouri L.
- Laboratory of Viral Pathogenesis, Institute for Virus Research, Kyoto University
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- HAYAMI Masanori
- Laboratory of Viral Pathogenesis, Institute for Virus Research, Kyoto University
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- MIURA Tomoyuki
- Laboratory of Viral Pathogenesis, Institute for Virus Research, Kyoto University
書誌事項
- タイトル別名
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- Characterization of vpr Vector Constructed from Chimeric Simian and Human Immunodeficiency Virus
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抄録
Chimeric simian and human immunodeficiency viruses (SHIVs) are useful tool for investigating AIDS pathogenesis and for development of vaccine. We constructed a SHIV-vpr vector (designated as SHIV-3sj) by replacing vpr region with restriction enzyme sites. SHIV-3sj was designed to express inserted gene along with its viral replication. Five cytokine genes were inserted into SHIV-3sj, and ability of viral replication and expression of the inserted genes were examined. The short insert including RANTES and IL-5 resulted in the successful expression from SHIV-3sj, while the construct having longer genes including IL-2, IL-6 and IL-12p35 failed to become replication competent. These results suggest that the length of the insert is an important factor for the replication ability of SHIV-3sj vector.<br>
収録刊行物
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- The Journal of Veterinary Medical Science
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The Journal of Veterinary Medical Science 65 (5), 633-636, 2003
公益社団法人 日本獣医学会
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詳細情報 詳細情報について
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- CRID
- 1390001206424828544
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- NII論文ID
- 110003886227
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- NII書誌ID
- AA10796138
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- COI
- 1:CAS:528:DC%2BD3sXkvFKisro%3D
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- ISSN
- 13477439
- 09167250
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- HANDLE
- 10458/2881
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- NDL書誌ID
- 6539716
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- PubMed
- 12808218
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可