Changes of Receptor mRNAs for Oxytocin and Estrogen during the Estrous Cycle in Rat Uterus
-
- MURATA Takuya
- Department of Physiology, Fukui Medical University
-
- NARITA Kazumi
- Department of Physiology, Fukui Medical University
-
- HONDA Kazumasa
- Department of Physiology, Fukui Medical University
-
- HIGUCHI Takashi
- Department of Physiology, Fukui Medical University
この論文をさがす
抄録
Oxytocin receptor (OTR) mRNA levels increase dramatically near term and is potently stimulated by estrogen because increased OTR mRNA levels result from estrogen treatment in ovariectomized rat uterus. In this study, OTR, estrogen receptor (ER) α and ERβ mRNA levels in the rat uterus during the estrous cycle were examined by quantitative RT-PCR. OTR mRNA levels during the estrous cycle began to increase on diestrus (P<0.05, vs value on estrus), reached maximal increase both in the morning (1000-1130 hr) and afternoon (1600-1630 hr) on proestrus (P<0.01, vs metestrus, diestrus and estrus) and then declined on estrus. In contrast ER α mRNA levels began to decrease on diestrus, reached statistical significance both in the morning and the afternoon on proestrus (P<0.01, vs metestrus, diestrus and estrus) and returned to the value of metestrus on estrus. ERβ mRNA levels were low in the morning and the afternoon on proestrus (P<0.01, vs metestrus and estrus) and also returned to metestrus values on estrus. Treatments with estrogen for 3 days significantly decreased both ERα and ERβ mRNA levels. It can be concluded from these results that during the estrous cycle, OTR mRNA levels in rat uterus predominantly increase at proestrus with a decrease in ERα and ERβ mRNA levels, which is probably due to the increased estrogen levels in circulation before ovulation.<br>
収録刊行物
-
- The Journal of Veterinary Medical Science
-
The Journal of Veterinary Medical Science 65 (6), 707-712, 2003
公益社団法人 日本獣医学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390282681401802624
-
- NII論文ID
- 110003886242
-
- NII書誌ID
- AA10796138
-
- COI
- 1:CAS:528:DC%2BD3sXmtFarurY%3D
-
- ISSN
- 13477439
- 09167250
-
- NDL書誌ID
- 6628044
-
- PubMed
- 12867731
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可