Attachment and Infection to MA104 Cells of Avian Rotaviruses Require the Presence of Sialic Acid on the Cell Surface
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- SUGIYAMA Makoto
- Laboratory of Zoonotic Diseases, Faculty of Agriculture, Gifu University
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- GOTO Kazuo
- Laboratory of Zoonotic Diseases, Faculty of Agriculture, Gifu University
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- UEMUKAI Hiroko
- Laboratory of Zoonotic Diseases, Faculty of Agriculture, Gifu University
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- MORI Yoshio
- Laboratory of Zoonotic Diseases, Faculty of Agriculture, Gifu University
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- ITO Naoto
- Laboratory of Zoonotic Diseases, Faculty of Agriculture, Gifu University
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- MINAMOTO Nobuyuki
- Laboratory of Zoonotic Diseases, Faculty of Agriculture, Gifu University
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Abstract
To determine the characters of receptors on target cells for avian rotaviruses, the receptors on MA104 cells for the pigeon rotavirus PO-13, the turkey rotaviruses Ty-1 and Ty-3, and the chicken rotavirus Ch-1 were analyzed. Pretreatment of MA104 cells with neuraminidase greatly reduced the infection by all of the four avian rotavirus strains. Binding of the cell-attachment protein, purified VP8 expressed in bacteria, of strain PO-13 to MA104 cells was also inhibited by pretreatment of cells with neuraminidase. These findings suggest that avian rotaviruses primarily utilize sialic acid-containing molecules as receptors on MA 104 cells.<br>
Journal
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- Journal of Veterinary Medical Science
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Journal of Veterinary Medical Science 66 (4), 461-463, 2004
JAPANESE SOCIETY OF VETERINARY SCIENCE
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Details 詳細情報について
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- CRID
- 1390282681404219648
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- NII Article ID
- 110003886430
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- NII Book ID
- AA10796138
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- ISSN
- 13477439
- 09167250
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- NDL BIB ID
- 6941591
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- PubMed
- 15133281
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed