Theileria sergenti のレセプターとしての赤血球膜ガングリオシド

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タイトル別名
  • Gangliosides as a Possible Receptor on the Bovine Erythrocytes for Theileria sergenti.
  • Theileria sergentiのレセプターとしての赤血球膜ガングリオシド〔英文〕
  • Theileria sergenti ノ レセプター トシテノ セッケッキュウ

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抄録

To elucidate whether or not gangliosides on the bovine erythrocytes serve as a receptor for Theileria sergenti merozoites, the reactivities of the T. sergenti piroplasms with gangliosides were studied by the liposome agglutination test. The parasites reacted weakly with I-active ganglioside containing N-acetylneuraminic acid (NeuAc) and strongly with I-active ganglioside containing N-glycolylneuraminic acid (NeuGc). However, none of the other gangliosides expressed on the bovine erythrocytes, such as GM3(NeuAc), GM3(NeuGc), sialosylparagloboside(SPG) (NeuAc), SPG(NeuGc), i-active ganglioside(NeuAc), and i-active ganglioside(NeuGc), were recognized. After infection with T. sergenti, furthermore, the content of I-active ganglioside(NeuAc) was less p < 0.05), and I-active ganglioside(NeuGc) content was much less in the erythrocytes (p < 0.01), though the contents of other NeuAc- and NeuGc-containing gangliosides did not so vary with T. sergenti infection. These results suggest that the parasites recognize the I-active ganglioside as their receptor and bind preferentially to NeuGc-carrying I-active ganglioside rather than to NeuAc-type in the target cell membranes, and that the reduction of the contents of I-active gangliosides(NeuAc and NeuGc) on the erythrocytes was related to T. sergenti infection.

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