泌乳牛における血漿1α, 25-dihydroxyvitamin D濃度に対する1α-hydroxyvitamin D<SUB>3</SUB>投与の影響

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タイトル別名
  • Effects of 1.ALPHA.-hydroxyvitamin D3 injection on plasma 1.ALPHA., 25-dihydroxyvitamin D concentration in lactating cows.
  • 泌乳牛における血漿1α,25-dihydroxyvitamin D濃度に対する1α-hydroxyvitamin D3投与の影響〔英文〕
  • ヒニュウギュウ ニ オケル ケッショウ 1 アルファ 25 dihydroxy

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The present study was carried out to compare the effects of the injection of 1α-hydroxyvitamin D3 (1αOHD3) on the plasma 1α, 25-dihydroxyvitamin D (1, 25(OH)2D) and calcium (Ca) concentrations in lactating cows, and to determine the efficacy of 1αOHD3 as prophylactic of parturient hypocalcemia. The cows were divided into two groups, a control group consisting of 6 cows and treatment (1αOHD3) group consisting of 5 cows. Each cow in the treatment group once received intramuscularly 500μg of 1αOHD3 resolved in 3ml ethanol. The plasma 1, 25 (OH)2D concentration in the 1αOHD3 group was significantly higher than that in the control group from 6hr to 5 days after injection, and became significantly lower than that in the control group at 10 days after injection. The plasma total Ca concentration was significantly higher in the 1αOHD3 group than that in the control group during 2 to 7 days after injection, while the plasma ionic Ca concentration in the former was significantly higher than that in the latter at 1, 2, 3, and 7 days after injection but lower than that at 14 days. Therefore, it is suggested to be appropriate for the prevention of the parturient hypocalcemia to inject 500μg of 1αOHD3 intramuscularly within 2 to 5 days before parturition. However, if 1αOHD3 was injected earlier than 10 days before parturition, this might produce a contrary result because the injection of 1αOHD3 caused the decrease of plasma 1, 25 (OH)2D and ionic Ca concentration at 10 and 14 days, respectively, after injection.

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