Establishment and Characterization of a New Cell Line Derived from Feline Mammary Tumor.
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- MULEYA Janet S.
- Department of Veterinary Surgery, Yamaguchi University
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- NAKAICHI Munekazu
- Department of Veterinary Surgery, Yamaguchi University
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- SUGAHARA Junya
- Department of Veterinary Surgery, Yamaguchi University
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- TAURA Yasuho
- Department of Veterinary Hospital, Yamaguchi University
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- MURATA Tomoaki
- Laboratory Animals, School of Medicine, Yamaguchi University
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- NAKAMA Sanenori
- Department of Veterinary Surgery, Yamaguchi University
書誌事項
- タイトル別名
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- Establishment and Characterization of a
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抄録
A new cell line designated FRM was established from pleural effusion of a 13-year-old female cat with mammary adenocarcinoma. The cell line exhibited irregular round and polygonal shaped epithelial cells and demonstrated cell growth in a monolayer fashion with a doubling time of 22.4 hr. It possessed a modal chromosome number of 79. The immortality of this cell line was demonstrated using the TRAP assay which revealed a high telomeric activity of these cells. Scatchard analysis revealed quite low levels of estrogen receptors in both tumor mass produced in nude mice and FRM cells. Subcutaneous transplantation of the cells produced localized palpable masses in athymic nude mice within two weeks. This cell line may provide a good model for in vivo and in vitro studies on feline mammary tumors.
収録刊行物
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- Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ Ｖｅｔｅｒｉｎａｒｙ Ｍｅｄｉｃａｌ Ｓｃｉｅｎｃｅ
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Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ Ｖｅｔｅｒｉｎａｒｙ Ｍｅｄｉｃａｌ Ｓｃｉｅｎｃｅ 60 (8), 931-935, 1998
公益社団法人 日本獣医学会
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詳細情報 詳細情報について
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- CRID
- 1390001206425111424
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- NII論文ID
- 110003918524
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- NII書誌ID
- AA10796138
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- COI
- 1:CAS:528:DyaK1cXmtFWnsb4%3D
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- ISSN
- 13477439
- 09167250
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- NDL書誌ID
- 4548529
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- PubMed
- 9764406
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可